停用地高辛与低血药浓度继续应用地高辛对慢性心力衰竭的效果  

Effects of Discontinuation of Digoxin Versus Continuation at Low Serum Digoxin Concentrations in Chronic Heart Failure

作　　者：Ahmed A. Gambassi G. Weaver M.T. 罗亮 

机构地区：[1]University of Alabama at Birmingham, Birmingham, AL, United States.Dr

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2007年第12期17-18,共2页

摘　　要：停用地高辛可引起心力衰竭(HF)症状恶化。然而,停用地高辛治疗对HF患者死亡率及发病率的长期影响尚未很好地研究。在地高辛调查组试验的7788例参与者中,3365例患者在随机化之前已接受了地高辛治疗。在该试验中,1666例患者继续使用地高辛,1699例患者停用地高辛。利用多变量Cox回归分析,首次确定了停用地高辛对中位期为39.7个月的随访内死亡率和住院率的影响。Discontinuation of digoxin is associated with worsening heart failure(HF) symptoms. However, the long-term effects of discontinuation of digoxin therapy on mortality and morbidity in HF have not been well studied. Of the 7,788 participants in the Digoxin Investigation Group trial, 3,365 received digoxin before randomization. During the trial, digoxin was continued in 1,666 patients and discontinued in 1,699 patients. Using multivariable Cox regression analyses, we first determined the effect of discontinuat...

关 键 词：地高辛 患者 停用 死亡率 狄戈辛 人口自然变动 全因死亡 住院率 

分 类 号：R541.6[医药卫生—心血管疾病]