修复周围神经损伤的静电自组装PDLLA/CS/CHS复合材料  

PDLLA/CS/CHS composite material for the regeneration of peripheral nerve prepared by LBL-ESA

作　　者：徐海星[1] 闫玉华[1] 梅玉峰[1] 李世普[1] 

机构地区：[1]武汉理工大学生物材料与工程研究中心

出　　处：《华中科技大学学报（自然科学版）》2007年第12期121-124,共4页Journal of Huazhong University of Science and Technology(Natural Science Edition)

基　　金：国家重点基础研究发展计划资助项目(2005CB623905)

摘　　要：利用静电自组装和真空冷冻干燥法制备用于修复周围神经损伤的聚乳酸/硫酸软骨素/壳聚糖复合材料.用全反射傅里叶红外光谱、扫描电子显微镜等进行表征,发现复合材料表面被均匀修饰,具有明显的多级结构,内层为致密结构,外层为疏松的海绵结构,孔径10~100μm.亲水性实验发现自组装复合材料的亲水性较纯聚乳酸有了较大的提高.降解实验发现:在0~2周,材料降解液pH值急剧下降,后期下降缓慢;降解过程中pH值都在7.0左右.MTT(四甲基偶氮唑盐)实验表明复合材料具有一定的促进雪旺细胞生长的作用.To prepare a PDLLA/chondroitin sulfate/chitosan multi-level composite scaffold for the regeneration of peripheral nerve via layer-by-layer(LBL) electrostatic-self-assembly(ESA) and thermally induced phase separation(TIPS) technique.The scaffold was characterized by attenuated total reflection ATR-FT-IR and scan electron microscope(SEM).The results showed the scaffold was modified uniformly and had an obvious multi-level structure with a dense inner layer and a porous sponge outer layer with the pore size ab...

关 键 词：周围神经 静电自组装 修复 聚乳酸 硫酸软骨素 壳聚糖 降解性能 

分 类 号：R651.3[医药卫生—外科学]