LM-BP-ANN算法应用于分光光度法同时测定治感冒药的4种组分  

Application of LM-BP-ANN Algorithm to the Simultaneous Spectrophotometric Determination of 4 Components in Colds-Curing Drugs

作　　者：张立庆[1] 程志刚[2] 李菊清[1] 余杞松 

机构地区：[1]浙江科技学院生物与化学工程学院,杭州310023 [2]浙江科技学院信息与电子工程学院,杭州310023

出　　处：《理化检验（化学分册）》2007年第11期906-909,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：浙江省自然科学基金项目(Y404082);浙江省高校中青年学科带头人资助项目

摘　　要：将LM-BP-ANN算法应用于分光光度法同时测定治感冒药中4个组分,即对乙酰氨基酚(ACET)、愈创木酚甘油醚(GUAI)、咖啡因(CAFF)及扑尔敏(CHLO)。应用此算法解决上述4组分吸收光谱相互重叠的问题,对分光光度测定的最优条件和网络参数的选择进行了试验和确定。结果表明:此算法的特点在于训练速度快,结果预报准确度高。分析了感冒咳嗽糖浆,可不经分离直接同时测定上述4组分,回收率试验的结果在99.0%~110.4%之间。The Levenberg-Marquardt BP-ANN algorithm was applied to the simultaneous spectrophotometric determination of acetaminophen,guaifenesin,caffeine and chlorphenamine maleate in colds-curing durgs,to overcome overlapping of absorption spectra of the 4 components.Optimum conditions of spectrophotometry and parameters of the network were tested and determined. Special features of the algorithm proposed were its rapidity of training and accuracy of result prediction.The 4 components in sample were determined direc...

关 键 词：分光光度法 LM-BP人工神经网络 对乙酰氨基酚 愈创木酚甘油醚 咖啡因 扑尔敏 治感冒药 

分 类 号：R927[医药卫生—药学]