盐酸吡格列酮的示波极谱测定  

Oscillopolarographic Determination of Micro-Amounts of Pioglitazone Hydrochloride

作　　者：魏小平[1] 李建平[1] 

机构地区：[1]桂林工学院材料与化学工程系,桂林541004

出　　处：《理化检验（化学分册）》2007年第11期910-912,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：广西自然科学基金(桂科自0679002;0728214);广西教育厅科研基金(桂教科200508135)资助

摘　　要：提出了测定微量盐酸吡格列酮的示波极谱法。在氨水-NH4Cl缓冲溶液中,盐酸吡格列酮在示波极谱仪上于-1.42 V处产生一灵敏的极谱还原波,导数波高与盐酸吡格列酮溶液质量浓度在0.4~40 mg.L-1范围内呈线性关系。优化了试验条件,对极谱波的行为和电极反应机理进行了研究,并测定了片剂样品中盐酸吡格列酮的含量,结果与标示值及高效液相色谱法测得结果相符,测定结果的RSD(n=10)值为3.04%。Oscillopolarography was applied to the determination of microamounts of pioglitazone hydrochloride in drugs.In an ammonicacal buffer of pH 8.8,a sensitive polarographic reductive wave given by pioglitazone was observed at-1.42 V(vs.SCE).Linear relationship between the values of 2st derivative of peak current(I″p) and concentration of pioglitazone was obtained in the range of 0.4-40 mg·L-1.Conditions for the method of determination were studied and optimized.The electrochemical behavior of pioglitazone at th...

关 键 词：盐酸吡格列酮 示波极谱法 测定 

分 类 号：R927[医药卫生—药学]