新藤黄酸亲水凝胶骨架缓释片的处方工艺研究  

Study on Compressed Hydrophilic Matrices Tablets of Neo-gumbogic Acid

作　　者：赵煤矿[1] 周晶[1] 周娟[1] 张帆[1] 王效山[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230038

出　　处：《安徽化工》2007年第5期32-33,共2页Anhui Chemical Industry

摘　　要：研制新藤黄酸亲水凝胶骨架缓释片并初步建立含量测定的方法。采用正交设计法,以崩解时间、缓释效果和pH值为指标综合评价筛选处方,用高效液相法测定制剂的含量。最佳处方为A2B2C3D1,即羟丙甲基纤维素K15M、乙基纤维素、乳糖的用量分别占片重的30%、6%、15%。高效液相法测定新藤黄酸含量在5.0-25.0μg/mL,线性良好。To prepare sustained-release matrix tablets of Neo-gumbogic acid.A tablet formulation of Neo-gumbogic acid containing Hydroxypropyl-methyl cellulose as matrix material was prepared by wetting-granule method.The drug release in virto was studied.The drug release from the matrix tablets is in compliance with Higuchi equation.The matrix tablets of Neo-gumbogic acid show perfect sustained-release effect.

关 键 词：新藤黄酸 亲水凝胶骨架片 

分 类 号：R914.4[医药卫生—药物化学] O656.31+[医药卫生—药学]