丹参酮ⅡA磺酸钠联合低分子肝素治疗不稳定心绞痛的临床研究  

Sodium tanshinone IIA silate combined with low molecular weight heparin sodium in treatment of unstable angina pectoris

作　　者：华宁[1] 唐发宽[1] 钮炜西[1] 王龙[1] 耿琪[1] 

机构地区：[1]解放军总医院第二附属医院心血管内科,北京100091

出　　处：《武警医学》2007年第3期195-198,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察丹参酮ⅡA磺酸钠(TSN)治疗不稳定性心绞痛的安全性及疗效。方法112例随机分为2组各56例,均予标准抗心绞痛治疗,治疗组在标准治疗基础上加用丹参酮ⅡA磺酸钠注射液治疗。观察治疗前后心绞痛缓解、心电图改善情况及血液流变学指标、治疗后24周内的心脏事件发生率。结果治疗组在心绞痛控制、心电图改善、血液流变学指标上有显著性差异(P<0.05);治疗后24周内治疗组心脏事件的发生率低于对照组。结论丹参酮ⅡA磺酸钠能改善不稳定性心绞痛患者临床症状,并可降低心绞痛的再发率和心脏事件的发生率。Objective To study the therapeutic efficacy and safety of Sodium tanshinone ⅡA silate in treatment of unstable angina.Methods A total of 112 patients with unstable angina pectoris were randomly assigned to either of two groups of 56 each:group A was treated with sodium tanshinone ⅡA silate injection on the basis of conventional anti-anginal treament where as group B with conventional anti-anginal therapy only.Symptoms,hemorrheology,and ECG were checked at one day before and after treatment,and the events of anginal affasks were observed through 24 weeks after treatment.Results In group A,the improtment in angiual symptoms,hemorheological parameters,and ECG were signiticantly superior to those in group B(P<0.05);The number of anginal heart events was also significantly reduced.Conclusion Sodium tanshinone ⅡA silate is an effective and safe drug in treatment of unstable angina pectoris.

关 键 词：丹参酮ⅡA磺酸钠 低分子肝素钠 不稳定性心绞痛 

分 类 号：R972+.3[医药卫生—药品]