环氧合酶-2在分娩发动中的作用及研究进展  

Progress in study on role of cyclooxygenase in initiation of parturition

作　　者：折开娥[1] 屈新中[1] 

机构地区：[1]西安交通大学医学院第一附属医院妇产科,陕西西安710061

出　　处：《中国妇幼健康研究》2007年第6期505-507,共3页Chinese Journal of Woman and Child Health Research

摘　　要：环氧合酶是花生四烯酸合成前列腺素过程中的限速酶,目前发现有3种同工酶,环氧合酶-1、环氧合酶-2以及新近发现的环氧合酶-3,与妊娠分娩发动有关的主要是诱导型环氧合酶-2,其在妊娠组织中都有一定量的表达,受多种因子诱导。随着妊娠进展,胎膜中环氧合酶-2表达增加,妊娠晚期更加显著,这与足月及早产的分娩发动密切相关。Cyclooxygenase is a rate-limiting enzyme in prostaglandin synthesis from arachidonic acid.Three cyclooxygenase isoenzymes(named as cyclooxygenase-1,cyclooxygenase-2 and cyclooxygenase-3 recently found) have been identified.The one associated with onset of labor is inducible type of cyclooxygenase-2,which is expressed in pregnant tissues at certain amount,and is induced by many factors.The impression level of Cyclooxygense-2 mRNA in fetal membranes increases alone with progression of pregnancy,especially in advanced weeks of congestation,which is closely associated with initiation of term and preterm parturition.

关 键 词：环氧合酶 前列腺素 分娩发动 胎膜 

分 类 号：R714[医药卫生—妇产科学]