局部松解配合骨生注射液对膝关节退行性变模型SOD、MDA的影响  

Effects of local lysis and Gusheng injection on levels of SOD and MDA in OA rabbits

作　　者：李霞玲[1] 章瑛[1] 周辉[1] 李家邦[1] 张花先[1] 

机构地区：[1]中南大学湘雅医学院中西医结合研究所,湖南长沙410008

出　　处：《中国现代医学杂志》2007年第8期936-938,共3页China Journal of Modern Medicine

基　　金：湖南省自然科学基金(99JJY2081)

摘　　要：目的探讨局部松解配合骨生注射液对膝关节退行性变(OA)模型局部组织匀浆超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法40只家兔随机分为空白对照组、局部松解组、骨生注射组及局部松解配合骨生注射组各10只。观察各组治疗前后局部组织匀浆中SOD、MDA的变化。结果3组治疗后SOD含量明显高于治疗前,MDA含量低于治疗前,统计学处<0.05;治疗后4组组间比较,局部松解配合骨生注射组与空白对照组比较,SOD及MDA含量无统计学意义;局部松解组及骨生注射组与空白对照组比较,SOD含量低于空白对照组,MDA含量高于空白对照组,统计学处理<0.05。结论3种治疗方法对实验性膝OA模型氧自由基代谢障碍均有影响;局部松解配合骨生注射组其疗效更优于其他两组。[Objective] To observe effects of local lysis and Gusheng injection on levels of SOD and MDA of tissue homognate in osteoarthriosis(OA)rabbits.[Methods] Forty rabbits were randomly divided into normal group(A),local lysis group(B),Gusheng injection group and local lysis && Gusheng injection group(D).Changes in SOD and MDA of tissue were investigated.[Results] Level of SOD was higher and level of MDA was lower after the treatments than before.After the treatments,the levels of SOD and MDA in D group showed no significant difference from that of A group.The other 2 treated groups had higher level of SOD and lower level of MDA than that of normal group.[Conclusion] The 3 treatments all had effects on free radical metabolism of experimental OA rabbits.Local lysis && Gusheng injection has better effect than the other 2 treatments.

关 键 词：实验性膝关节退变 局部松解 骨生注射法 氧自由基代谢 

分 类 号：R684[医药卫生—骨科学]