干扰素联合胸腺肽治疗慢性乙型肝炎35例护理体会  

Experience of nursing care of 35 cases of chronic hepatitis B treated with interferon combined with thymopeptide

作　　者：张红梅[1] 韩润花 王丽芳[1] 张月铭[1] 

机构地区：[1]大同市第四人民医院,山西大同037008

出　　处：《齐鲁护理杂志》2007年第23期7-8,共2页Journal of Qilu Nursing

摘　　要：目的:探讨干扰素联合胸腺肽治疗慢性乙型肝炎的护理方法。方法:将70例慢性乙型肝炎患者随机分为治疗组和对照组各35例,两组均给予干扰素(α-1b)500万U,隔日肌内注射,疗程6个月,治疗组同时给予胸腺肽100mg静脉滴注,疗程为3个月,后3个月隔日肌内注射胸腺肽20mg;对照组同时给予5%葡萄糖注射液250m l+维生素C 2g+维生素B60.2g+肌苷0.4g+三磷酸腺苷二钠40mg静脉滴注,疗程3个月。结果:治疗6个月后,治疗组HBeAg、HBV-DNA转阴情况与对照组比较差异有极显著性(P<0.01),两组总有效率比较有显著性差异(P<0.05)。结论:干扰素联合大剂量胸腺肽能提高抗乙肝病毒复制的疗效。Objective:To explore the nursing methods in the treatment of chronic hepatitis B by interferon combined with thymopeptide.Methods:Seventy patients with chronic hepatitis B were randomly divided into treatment group (n=35) and control group(n=35).Interferon(α-1b) in 5 million U was given to the patients in the two groups by intramuscular injection every other day,the period of treatment was 6 months.In addition,100mg thymopeptide was given by intravenous infusion for 3 months in treatment group and the patients were injected 20mg thymopeptide intramuscularly every other day in the latter 3 months.In control group,patients were intravenously given 250ml glucose in 5% with 2g vitamin C,0.2g vitamin 6,0.4g Inosine and 40mg ATP together for 3 months.Results:The significant differences were found in the comparison of HBeAg and HBV-DNA after treatment for 6 months(P<0.01) and there was also significant difference in the total effective rate between the two groups(P<0.05).Conclusion:It is effective to increase the curative effect in anti-duplication of hepatitis B virus by applying interferon combined with large doge of thymopeptide in the treatment of chronic hepatitis B.

关 键 词：慢性乙型肝炎 干扰素 胸腺肽 联合治疗 

分 类 号：R47[医药卫生—护理学]