祛风宣痹方对哮喘豚鼠细胞粘附分子的影响  

influence of Qufeng Xuanbi Formula on ICAM-1 of Asthma Guinea Pig

作　　者：史锁芳[1] 吴寒[1] 范一平[1] 朱萱萱[1] 赖仁胜[1] 

机构地区：[1]南京中医药大学附属医院,南京210029

出　　处：《浙江中医药大学学报》2007年第6期695-,698,共2页Journal of Zhejiang Chinese Medical University

基　　金：江苏省中医药管理局课题(No:苏中医政[2005]29号)~~

摘　　要：[目的]探讨祛风宣痹方(平哮合剂)对支气管哮喘的作用机理。[方法]用卵蛋白致敏豚鼠复制支气管哮喘动物模型,用祛风宣痹方(平哮合剂)治疗,观察动物血浆中细胞粘附分子(ICAM-1)水平的变化。[结果]实验性哮喘豚鼠发作时血浆中细胞粘附分子(ICAM-1)水平显著高于正常对照组,祛风宣痹方(平哮合荆)对实验性哮喘豚鼠中细胞粘附分子(ICAM-1)水平有明显降低作用(95%可信区间为20.387～53.834u/ml)(P<0.01)。[结论]祛风宣痹方(平哮合荆)有效治疗哮喘的作用与抑制细胞粘附分子(ICAM-1)产生密切相关。[Objective]To discuss the functional mechanism of Qufeng Xuanbi(remove wind and apoplexy)Formula(Pingxiao Heji) on bronchia asthma.[Method]Make bronchia asthma animal model with guinea pig sensitized by egg albumen,treat it with Qufeng Xuanbi Formula,observe the changes of cell adhesion molecular(ICAM-1)in animal plasma.[Result]When experimental guinea pig was attacked by asthma,the ICAM-1 was obviously more than that in normal control group,the formula could markedly lower ICAM-1(95% of the believable zone 20.387～53.834u/ml)(P<0.01).[Conclusion]Qufeng Xuanbi Formula can effectively treat asthma,which is closely related with ICAM-1.

关 键 词：祛风宣痹方 哮喘 细胞粘附分子 病理形态学 实验研究 

分 类 号：R285.5[医药卫生—中药学]