应用KF-Al_2O_3作催化剂合成2-庚酮  

Synthesis of 2-Heptanone Catalyzed by KF-Al_2O_3

作　　者：啜惠民[1] 朱宝昌[1] 赵惠芝[1] 朱兆富[1] 周永国[1] 

机构地区：[1]河北科技师范学院,河北秦皇岛066600

出　　处：《河北科技师范学院学报》2006年第2期12-14,共3页Journal of Hebei Normal University of Science & Technology

摘　　要：研究了用KF-Al2O3作催化剂,正溴丁烷与乙酰乙酸乙酯的化学反应,以正丁基取代乙酰乙酸乙酯中的α-H,实现了碳—碳烷基化反应,合成了正丁基乙酰乙酸乙酯,再经水解脱羧制得2-庚酮,收率为72.5%,比常规醇钠法制得2-庚酮的收率提高了14.5个百分点。It was studied that n-butane bromide react with ethyl acetoacetate catalyzed by KF-Al_2O_3.In the reaction,normal butyl replace α-H of ethyl acetoacetate,alkylation was realized and formed n-butyl ethyl acetoacetate.The product hydrolyze and eliminated carboxyl formed 2-Heptanone.The yield is 72.5%,higher 14.5% than routine method of sodium alcoholate.

关 键 词：2-庚酮 有机合成 KF-AL2O3 碳-碳烷基化 

分 类 号：O623.524[理学—有机化学]