叶酸联合甲钴胺治疗尿毒症颈动脉粥样硬化60例效果观察  

Observation of the therapeutic effect of folic acid combined with mecobalamin in the treatment of 60 patients with uremic carotid atherosclerosis and nursing care

作　　者：谢映辉[1] 程树红[1] 丁少波[1] 

机构地区：[1]东莞市人民医院,广东东莞523018

出　　处：《齐鲁护理杂志》2007年第9期9-10,共2页Journal of Qilu Nursing

摘　　要：目的:探讨叶酸联合甲钴胺治疗尿毒症颈动脉粥样硬化患者的效果及护理。方法:将120例尿毒症颈动脉粥样硬化患者随机分为对照组和治疗组各60例,对照组常规治疗,治疗组在常规治疗基础上行叶酸联合甲钴胺干预性治疗,6个月后测定两组治疗前后颈动脉内-中膜厚度(IMT)、颈动脉血流动力学参数、颈动脉粥样硬化斑块数量和超声分型的变化。结果:治疗组6个月后与治疗前相比颈动脉IMT变薄,最小血流速度(DV)变快,血流阻力指数(RI)下降,均有显著性改善(P<0.05);对照组无显著性改变(P>0.05)。两组治疗后粥样斑块扁平斑和软斑数量减少有显著性差异(P<0.01)。结论:叶酸联合甲钴胺治疗尿毒症颈动脉粥样硬化患者,能显著提高其生存率和生存质量。Objective: To observe the effect of folic acid combined with mecobalamin in the treatment of patients with uremic carotid atherosclerosis and nursing care.Methods: One hundred and twenty patients with uremic carotid atherosclerosis were randomly divided into treatment group(n=60) and control group(n=60),routine treatment was taken in control group and folic acid combined with mecobalamin was applied in treatment group.Six months later,the determination of IMT,haemodynamics parameter of carotid atherosclerotic,the number of carotid atherosclerotic plaque and the change of typing of ultrasonic before and after treatment were carried out in the two groups.Result: After treatment for 6 months,IMT of arteria carotis was thinner,minimum DV was fast and RI was lower(P<0.05),but no significant difference was found in control group(P>0.05).The number of flat spot and blet obviously decreased and significant difference was found(P<0.01).Conclusion: The therapy of folic acid combined with mecobalamin can effectively improve patient's conditions and quality of life and increase the rate of survival.

关 键 词：叶酸 甲钴胺 尿毒症 颈动脉粥样硬化 

分 类 号：R473.5[医药卫生—护理学]