大肠埃希菌产超广谱β-内酰胺酶的危险因素研究  

Epidemiological study on Escherichia coli producing extended-spectrum β-lactamases

作　　者：黄瑞娟[1] 叶临湘[1] 冯启明[2] 

机构地区：[1]华中科技大学同济医学院 [2]广西医科大学公共卫生学院,广西南宁530021

出　　处：《疾病控制杂志》2008年第2期141-143,共3页Chinese Journal of Disease Control and Prevention

摘　　要：目的探索大肠埃希菌(E.coli)产超广谱β-内酰胺酶(ESBLs)的危险因素,为制定预防控制策略提供科学依据。方法采用抑制剂增强双纸片扩散法检测ESBLs,以桂林某医院微生物实验室首次分离产ESBLs E.coli的病例为病例组,非产ESBLs E.coli的病例为对照组,采用logistic回归分析进行研究。结果213例病例分离出E.coli ESBLs 111例,ESBLs总体阳性率为52.11%,外科阳性率为61.36%,高于内科45.60%。医院感染、住院时间≥7d、联用抗生素、三代头孢菌素、氟喹诺酮类抗菌药物和β-内酰胺酶抑制剂复合抗生素使用是E.coli产ESBLs的危险因素,其中住院时间≥7d、三代头孢菌素和联用抗生素是独立危险因素。结论住院病人E.coli的ESBLs阳性率高,产ESBLs危险因素复杂多样,应该采取综合措施来预防和控制产ESBLs菌株的流行。Objective To explore the risk factors for Escherichia coli(E.coli)producing extended-spectrum β-lactamases(ESBLs).Methods The isolate rates of 111 cases of E.coli producing ESBLs and 102 cases of control not producing ESBLs were analysed with logistic regression.Results The isolate rate of E.coli was 52.11%.The isolate rate of surgery(61.36%)was higher than that of internal medicine.Hospital infection,hospital stay over 7 days,combined use of antibiotics,use of 3 rd generation cephalosporins,use of the quin...

关 键 词：大肠杆菌 危险因素 病例对照研究 

分 类 号：R516[医药卫生—内科学]