谷氨酰胺对创伤性脑损伤后肠黏膜超微结构和细胞凋亡的影响  

Influence of glutamine on ultrastructure and apoptosis of intestinal mucosa after traumatic brain injury in rats

作　　者：李鸣[1] 杭春华[2] 史继新[2] 陈罡[2] 

机构地区：[1]解放军第八一医院神经外科,江苏南京210002 [2]南京军区南京总医院神经外科,江苏南京210002

出　　处：《肠外与肠内营养》2008年第1期20-22,共3页Parenteral & Enteral Nutrition

摘　　要：目的:探讨谷氨酰胺(Gln)对创伤性脑损伤(TBI)后大鼠肠黏膜超微结构和细胞凋亡的影响。方法:将54只大鼠随机分为对照组(N组,6只)、脑损伤组(TBI组,24只)和脑损伤后Gln治疗组(Gln组,24只),TBI组和Gln组按脑损伤后检测时间再分为1、3、5、7 d组,每组6只大鼠,对回肠黏膜行电镜检查,并以TUNEL法观察细胞凋亡。结果:TBI后3 d肠黏膜超微结构的损伤及细胞凋亡达到高峰,Gln可使细胞凋亡下调,明显减轻肠黏膜超微结构的损伤。结论:Gln能抑制TBI后肠黏膜细胞凋亡,保护肠黏膜结构。Objectives:To investigate the influences of glutamine on ultrastructure and apoptosis of intestinal mucosa after traumatic brain injury(TBI) in rats.Methods:Fifty four adult male Wistar rats were divided randomizely into three groups,including control group(N group,6 cases),TBI group(T group,24 cases) and Gln intervention group(Gln group,24 cases).According to the testing time after TBI,T group and Gln group were again divided into 1 d,3 d,5 d,7 d groups respectively.Ileal mucous membrane was observed under...

关 键 词：谷氨酰胺 创伤性脑损伤 肠黏膜 凋亡 

分 类 号：R651.15[医药卫生—外科学]