斑秃患者外周血单个核细胞产生Th1/Th2细胞因子研究  

Study of Th1/Th2 cytokines produced by peripheral blood mononuclear cells from Alopecia Areata patients

作　　者：李建红[1] 李萍[1] 刘建中[1] 刘启文[1] 

机构地区：[1]广东省深圳市儿童医院皮肤科,广东深圳518026

出　　处：《岭南皮肤性病科杂志》2008年第2期61-63,共3页Southern China Journal of Dermato-Venereology

摘　　要：目的:研究斑秃患者外周血单个核细胞产生Th1型细胞因子(如IFN-γ)和Th2型细胞因子(如IL-4、IL-10)水平,探讨其在斑秃发病中所起的作用及与病情活动性的关系。方法:采用ELISA双抗体夹心法检测36例斑秃患者(其中活动期19例、非活动期17例)和20例正常对照者外周血单个核细胞产生IFN-γ、IL-4和IL-10水平。结果:活动期斑秃患者外周血单个核细胞产生IFN-γ水平显著高于正常对照和非活动期患者(P<0.05),非活动期患者比正常对照者明显增高(P<0.05);活动期患者产生IL-4水平明显低于正常对照组(P<0.05),也低于非活动期患者,但差异无统计学意义(P>0.05),非活动期患者和正常对照组相比明显降低(P<0.05);活动期患者产生IL-10水平显著低于正常对照组和非活动期患者(P<0.05),非活动期患者与正常对照相比明显降低(P<0.05)。结论:斑秃患者体内可能存在Th1型细胞因子占优势,Th1型细胞因子如IFN-γ在斑秃的免疫发病中起到重要作用,并且与病情活动性有关联。Objective:To detect the levels of Th1 cytokines such as IFN-γ and Th2 cytokines such as IL-4 and IL-10 produced by peripheral blood mononuclear cells from patients with alopecia areata(AA),and to investigate their roles in the pathogenesis of AA and the relationship between these cytokines and the disease activity.Methods:The levels of IFN-γ,IL-4 and IL-10 secreted by peripheral blood mononuclear cells from 36 AA patients(19 active cases and 17 non-active cases) and 20 normal controls were measured by enzym...

关 键 词：斑秃 外周血单个核细胞 TH细胞 IFN-γ 白介素-4 白介素-10 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]