衣霉素对胶原性关节炎小鼠免疫功能影响的研究  

Effect of tunicamycin on type Ⅱ collagen-induced arthritis mice

作　　者：刘文波[1] 梁婧[1] 潘文萍[1] 刘海荣[1] 孙殿水[1] 

机构地区：[1]山东省千佛山医院,山东济南250014

出　　处：《山东医药》2008年第5期29-31,共3页Shandong Medical Journal

摘　　要：目的探讨衣霉素治疗Ⅱ型胶原性关节炎(CIA)的作用机制。方法将48只小鼠随机分为对照组,模型组,衣霉素低、中、高剂量组和地塞米松组。除对照组外均行CIA造模,造模后衣霉素3个剂量组和地塞米松组分别腹腔注射衣霉素5、25、50μg/kg和地塞米松0.2mg/kg,1次/d,连续7d。观察各组关节炎发生情况,检测脾脏淋巴细胞增殖反应,测定迟发性变态反应(DTH)和血清抗CⅡ抗体,同时行病理组织学检查。结果中、高剂量衣霉素组和地塞米松组关节炎炎症评分、脾脏淋巴细胞增殖反应、DTH反应及血清中抗CⅡ抗体、滑膜增生和软骨破坏程度均较衣霉素低剂量组和模型组减轻或降低(P均<0.05)。结论衣霉素对CIA大鼠免疫功能具有抑制作用,且呈浓度依赖性,此可能为其治疗CIA的机制。Objective To study the effect of tunicamycin on type Ⅱ collagen-induced arthritis(CIA)mice.Methods Type Ⅱ collagen(CⅡ)was used to induced CIA in mice and the changes of inflammatory and immune function in CIA mice treated with tunicamycin were observed.Results Tunicamycin(25,50μg·kg-1)significantly decreased arthritis scores and pathologic change in joints of CIA mice.There was a significant reduction in proliferation of splenic lymphocytes and the delayed-type hypersensitivity(DTH)reaction of CIA mice trea...

关 键 词：衣霉素 Ⅱ型胶原性关节炎 类风湿关节炎 

分 类 号：R593.2[医药卫生—内科学]