使用3-back范式比较不同COMTVal 158Met多态型的健康青年在连续心算中的视觉事件相关电位  

Comparison of Visual Evoked Related Potentials in Healthy Young Adults of Different COMT Genotypes by Using a 3-back Paradigm During A Continuous Mental Arithmetic Task

作　　者：岳春林[1] 孙学川[1] 刘卓[2] 邓伟明[2] 

机构地区：[1]四川大学华西医学中心生物医学工程研究室,成都610041 [2]解放军军事体育进修学院,广州510502

出　　处：《生物医学工程学杂志》2008年第3期562-566,共5页Journal of Biomedical Engineering

摘　　要：针对不同COMT基因型健康青年被试者,进行连续心算任务3h,使用数字3-back范式评定健康成人数字工作记忆能力变化情况。我们将115名健康青年分组抽取出20名不同基因型作为被试者,利用事件相关视觉诱发电位P3来观测被试者连续工作记忆任务中COMT基因多态型与脑皮层电生理的关系。结果表明,Val/Val基因型的被试者P3波幅显著高于Val/Met基因型(P<0·01),与Met/Met基因型被试者的P3波幅无差异;在不同Block,不同基因型出现P3波幅增加的趋势。我们认为,数字工作记忆能力和中央区、顶区诱发的P3波幅相关,这反映了任务对被试者的难易程度。To explore the change of numerical working memory ability in healthy young adults, continuous mental arithmetic task were performed for 3 hours and a numerical working memory paradigm was determined at 5 min intervals according to different COMT genotypes of young adults.Twenty subjects of different genotypes were chosen from 115healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task...

关 键 词：儿茶酚胺氧甲基转移酶 P3 工作记忆 

分 类 号：R318[医药卫生—生物医学工程]