定向冠状动脉粥样斑块旋切术切取的不稳定斑块中白介素-10的表达增加  

Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy

作　　者：Nishihira K. Imamura T. Yamashita A. 刘少伟 

机构地区：[1]First Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2006年第12期34-34,共1页

摘　　要：Aims: The present study investigates the expression and localization of interleukin(IL)-10, an important anti-inflammatory cytokine, in atherectomy specimens from patients with stable and unstable angina. Methods and results: Twenty-two patients with stable angina and 21 with unstable angina who underwent directional coronary atherectomy for de novo lesions were studied. The atherectomy specimens were morphologically assessed and immunohistochemically stained with antibodies for IL-10, macrophages, smoothmuscle cells, and endothelial cells. The localization and immunopositive areas were evaluated using an image analysing system. Immunoreactivity for IL-10 was detected in coronary plaques, especially in macrophages. Immunopositive areas of macrophages and IL-10, as well as the incidence of thrombus formation, were significantly greater in specimens from patients with unstable angina than in those from patients with stable angina(macrophages, P< 0.001; IL-10, P< 0.05; thrombus formation, P< 0.05; respectively). Even after adjustment, IL-10 expression and the incidence of thrombus formation were significantly greater in the unstable angina group(P< 0.05, each). The immunoreactivities for smooth muscle cells and endothelial cells did not differ between the two groups. Conclusion: IL-10 was more frequently expressed in specimens from patients with unstable angina. This finding might contribute to a better understanding of plaque instability.Aims: The present study investigates the expression and localization of interleukin(IL)-10, an important anti-inflammatory cytokine, in atherectomy specimens from patients with stable and unstable angina. Methods and results: Twenty-two patients with stable angina and 21 with unstable angina who underwent directional coronary atherectomy for de novo lesions were studied. The atherectomy specimens were morphologically assessed and immunohistochemically stained with antibodies for IL-10, macrophages, smoothmu...

关 键 词：冠状动脉粥样斑块 不稳定型心绞痛 患者 IL 斑块旋切 白介素 旋切术 

分 类 号：R654.2[医药卫生—外科学]