慢性荨麻疹患者的单克隆丙种球蛋白病和恶性疾病  

Monoclonal gammopathies and malignancies in patients with chronic urticaria

作　　者：Karakelides M. Monson K.L. Volcheck G.W. Weiler C.R 董平 

机构地区：[1]Division of Allergic Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期22-23,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Monoclonal gammopathy of undetermined significance (MGUS) has been described in association with chronic urticaria (CU) in patients with Schnitzler syndrome. Chronic urticaria may be a manifestation of hematologic malignancies. Methods: This study was conducted to evaluate the frequency and characteristics of MGUS or malignancy in patients with CU. The Mayo Clinic electronic database was reviewed to identify patients with the diagnosis of CU. Results: Of the 1639 patients presenting with CU between 1994 and 2001, 797 (49%) underwent laboratory evaluation for the presence of a coexisting monoclonal protein. Forty-seven CU patients had MGUS, 142 had a malignancy, and 24 had both. Fifteen percent of CU patients with MGUS had a hematologic malignancy compared with 0.9%of CU patients without MGUS (P < 0.001). Patients presenting with a new diagnosis of CU at an older age (> 56.years) were more likely to have associated underlying MGUS. The occurrence of MGUS in this groupwas higher than the reported incidence of MGUS in the general population. Conclusions: Patients with CU younger than 43 years were unlikely to have associated MGUS or malignancy. A higher percentage of patients with CU and MGUS had an associated diagnosis of hematologic malignancy.Background: Monoclonal gammopathy of undetermined significance (MGUS) has been described in association with chronic urticaria (CU) in patients with Schnitzler syndrome. Chronic urticaria may be a manifestation of hematologic malignancies. Methods: This study was conducted to evaluate the frequency and characteristics of MGUS or malignancy in patients with CU. The Mayo Clinic electronic database was reviewed to identify patients with the diagnosis of CU. Results: Of the 1639 patients presenting with CU betw...

关 键 词：慢性荨麻疹 单克隆 恶性疾病 丙种球蛋白 单纯蛋白 患者 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]