接受低剂量甲氨蝶呤治疗患者发生不典型皮肤利什曼病2例  

Atypical cutaneous leishmaniasis in two patients receiving low-dose methotrexate

作　　者：Saha M. Shipley D. McBride S. 冯义国 

机构地区：[1]Department of Dermatology, Royal Free Hospital, London,United Kingdom

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期18-18,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Cutaneous leishmaniasis is a protozoan disease that has high morbidity. There have been increasing reports of leishmaniasis in patients with an underlying immunosuppressed state. We present two cases of cutaneous leishmaniasis caused by Old World species in patients on methotrexate therapy. We postulate that the T-cell-mediated response to leishmaniasis infection could be modulated by methotrexate and may render an immunosuppressed individual more susceptible to developing clinical disease.Cutaneous leishmaniasis is a protozoan disease that has high morbidity. There have been increasing reports of leishmaniasis in patients with an underlying immunosuppressed state. We present two cases of cutaneous leishmaniasis caused by Old World species in patients on methotrexate therapy. We postulate that the T-cell-mediated response to leishmaniasis infection could be modulated by methotrexate and may render an immunosuppressed individual more susceptible to developing clinical disease.

关 键 词：皮肤利什曼病 东方疖 甲氨蝶呤 患者 

分 类 号：R757[医药卫生—皮肤病学与性病学]