尼日利亚的固定性药疹  

Fixed drug eruption in Nigeria

作　　者：Nnoruka E.N Ikeh V.O. Mbah A.U. 周炳荣 

机构地区：[1]Sub-Department of Dermatology, College of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期25-26,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Fixed drug eruption (FDE) causes cosmetic embarrassment in Nigerian patients, particularly when the characteristic hyperpigmented patches affect the face and lips. Drugs that have been implicated in the etiology of FDE, and the sites of lesions, may vary from country to country. Antimalarials, such as Fansidar, Fancimef, Maloxine, Amalar, and Metakelfin, were the most common offending agents, accounting for 38%of FDEs, followed by trimethoprim +sulfamethoxazole (co-trimoxazole) (28%), dipyrones (10%), Butazolidin (6%)-, thiacetazone (6%), metronidazole (4%), paracetamol (3%), and naproxen (3%). Lesions induced by the combination of sulfadoxine and pyrimethamine (in antimalarials) mainly involved the face and lips. In most cases, patients took these sulfa-containing antimalarials in combination with numerous other drugs, particularly analgesics. Unlike chloroquine-induced pruritus, which affects most Africans, the association between antimalarials and FDE has not been well documented in our region. Co-trimoxazole was associated more often than antimalarials with FDEs involving the mucocutaneous junctions of the genitalia and lips. Males with genital lesions on the glans penis represented 11 (48%) of those with co-trimoxazole hypersensitivity. The trunk and limbs were affected mainly by pyrazoles and Butazolidin, respectively; however, solitary lesions on the trunk were usually due to co-trimoxazole, whereas solitary lesions on the limbs were associated with Butazolidin.Fixed drug eruption (FDE) causes cosmetic embarrassment in Nigerian patients, particularly when the characteristic hyperpigmented patches affect the face and lips. Drugs that have been implicated in the etiology of FDE, and the sites of lesions, may vary from country to country. Antimalarials, such as Fansidar, Fancimef, Maloxine, Amalar, and Metakelfin, were the most common offending agents, accounting for 38%of FDEs, followed by trimethoprim +sulfamethoxazole (co-trimoxazole) (28%), dipyrones (10%), Butaz...

关 键 词：固定性药疹 固定疹 抗疟药 抗原虫药 复方新诺明 尼日利亚 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]