乌干达自身免疫性表皮下水疱性疾病:自身抗体类别和年龄的相关性  

Autoimmune subepidermal blistering diseases in Uganda:Correlation of autoantibody class with age of patients

作　　者：Mulyowa G.K Jaeger G. Kabakyenga J. E. Schmidt 董平 

机构地区：[1]Department of Dermatology,University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期24-24,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous membranes that attended the Department of Dermatology at Mbarara University, Uganda, from May 2000 to June 2002, were investigated. The diagnosis was based on the clinical presentation and on the presence of circulating autoantibodies detected by indirect immunofluorescence microscopy on 1M NaCl-split human skin and by Western blotting of recombinant and cell-derived forms of BP180, BP230, and type VII collagen. Results: Twenty two patients with autoimmune subepidermal blistering skin disorders were identified, including nine with bullous pemphigoid pemphigoid(41%), four with linear immunoglobulin A (IgA) disease (18%), three with mucous membrane pemphigoid (14%), two with linear IgG/IgA bullous dermatosis (9%), and one each with cicatricial pemphigoid and epidermolysis bullosa acquisita (5%). In addition, two patients with immunoreactivity to both the epidermal and dermal side of salt-split skin by indirect immunofluorescence microscopy, who were unreactive to type VII collagen, were provisionally diagnosed as “mixed pemphigoid”(9%). In patients with subepidermal blistering diseases, IgG reactivity correlated significantly with old age, whereas younger patients preferentially developed IgA autoantibodies (P = 0.024). Conclusions: The age of patients with autoimmune subepidermal blistering diseases appears to influence the immunoglobulin class of autoantibodies. The high frequency of IgA autoantibodies in Ugandan patients may be explained by the age distribution of the Ugandan population.Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous membranes that attended the Department of Dermatology at Mbarara University, Uganda, from May 2000 to June 2002, were investigated. The diagnosis was based on the clinical presentation and on the presence of circulating autoantibodies detected by indirect immunofluorescence microscopy on 1M NaC...

关 键 词：表皮 皮肤 类天疱疮 大疱性皮肤病 水疱 自身免疫性 自身抗体 乌干达 性疾病 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]