金黄色葡萄球菌在湿疹和特应性皮炎患者的皮肤定殖以及与局部治疗的关联性:一项双盲、多中心、随机对照试验  

Skin colonization by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy:A double-blind multicentre randomized controlled trial

作　　者：张路坤 

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期9-10,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Staphylococcus aureus has a peculiar ability to colonize the skin of patients with eczema and atopic dermatitis (AD), and is consistently found in eczematous skin lesions in these patients. A correlation between the severity of the eczema and colonization with S. aureus has been demonstrated, and it has been determined that bacterial colonization is an important factor aggravating skin lesions. Patients colonized with S. aureus have been treated with antibiotics in several open and double-blind placebo-controlled studies, with conflicting results. Objectives: To investigate the colonizing features of S. aureus in the lesional and nonlesional skin of patients with eczema and AD in China and to compare the therapeutic effect of mupirocin plus hydrocortisone butyrate with vehicle ointment plus hydrocortisone butyrate. Methods: A multicentre,double-blind randomized trial was conducted. Eczema Area and Severity Index (EASI) scores were evaluated before the start of the trial and on the 7th, 14th and 28th day of treatment. Swabs for bacterial isolation were taken from lesional skin before the start of the trial and on the 7th, 14th and 28th day of treatment, and from nonlesional skin only before the start of the trial. A combination topical therapy with mupirocin plus hydrocortisone butyrate ointment was used in the experimental group, with vehicle ointment plus hydrocortisone butyrate ointment as a control. Results: Of 327 patients enrolled in the study, 208 had eczema and 119 had AD. Bacteria were isolated from 70.2%of lesional and 32.7%of nonlesional skin samples from patients with eczema, of which S. aureus accounted for 47.3%and 27.9%, respectively. Bacteria were isolated from 74.8%of lesional and 34.5%of nonlesional skin samples from patients with AD, of which S. aureus accounted for 79.8%and 80.5%, respectively. The colonization density of S. aureus was markedly higher in lesional than in nonlesional skin, both in patients with eczema and with AD (P < 0.01, P < 0.05), and was positively correlated wiBackground: Staphylococcus aureus has a peculiar ability to colonize the skin of patients with eczema and atopic dermatitis (AD), and is consistently found in eczematous skin lesions in these patients. A correlation between the severity of the eczema and colonization with S. aureus has been demonstrated, and it has been determined that bacterial colonization is an important factor aggravating skin lesions. Patients colonized with S. aureus have been treated with antibiotics in several open and double-blind ...

关 键 词：湿疹 AD 金黄色葡萄球菌 患者 局部治疗 特应性皮炎 变态反应病 皮肤 解剖部位 定殖 双盲 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]