2次/d应用钙泊三醇软膏和1次/d短期应用地蒽酚乳膏治疗:一项按日间用药程序指导性治疗寻常型银屑病的随机对照试验  

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy:A randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

作　　者：Van De Kerkhof P.C.M. Van Der Valk P.G.M. Swinkels O.Q.J 周少娜 

机构地区：[1]Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, Netherlands

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第12期15-16,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Calcipotriol has become a first-line treatment for psoriasis. Its efficacy and safety have been shown in many comparative clinical trials carried out in outpatients. In a comparative study in patients visiting the outpatient department once every 14 days, it was shown that calcipotriol was more effective and better tolerated compared with dithranol. Objectives: To compare the clinical efficacy of calcipotriol ointment with that of dithranol cream in a supervised treatment regimen. Methods: In a multicentre randomized controlled trial in six centres in the Netherlands, 106 patients with chronic plaque psoriasis were included, 54 receiving calcipotriol ointment twice daily and 52 dithranol cream once daily. Patients were treated at the day-care centre, using the care instruction principle of daily visits during the first week and twice-weekly visits subsequently for up to 12 weeks. Results: This study failed to prove that calcipotriol is as efficacious as dithranol when used in a day-care setting (noninferiority test). The mean percentage reduction in Psoriasis Area and Severity Index from baseline to end of treatment was 57.0%in the calcipotriol group vs. 63.6%in the dithranol group. However, the two-sided test for superiority indicated no statistically significant difference between the treatment groups (P = 0.39). At the end of treatment, 15%of the patients treated with calcipotriol ointment and 25%of those treated with dithranol cream did not require any further treatment. Although calcipotriol ointment appeared to be more effective during the first 8 weeks, a difference was no longer apparent at 12 weeks. In comparison with the high number of drop-outs due to cutaneous side-effects in the calcipotriol group, the frequency of a tolerable degree of irritation appeared to be higher in patients treated with dithranol. However, concomitant corticosteroid treatment of dithranol irritation in seven patients may have contributed to this difference between both treatments. Moreover, patients receiving theraBackground: Calcipotriol has become a first-line treatment for psoriasis. Its efficacy and safety have been shown in many comparative clinical trials carried out in outpatients. In a comparative study in patients visiting the outpatient department once every 14 days, it was shown that calcipotriol was more effective and better tolerated compared with dithranol. Objectives: To compare the clinical efficacy of calcipotriol ointment with that of dithranol cream in a supervised treatment regimen. Methods: In a ...

关 键 词：钙泊三醇 卡泊三醇 地蒽酚 乳膏 软膏 膏剂 用药 随机对照试验 程序 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]