β3肾上腺素能受体基因多态性与新疆哈萨克族人群高血压病的相关研究  

Association of Essential Hypertension and Polymorphism of β3-adrenergic Receptor Gene in Xinjiang Kazak Population

作　　者：郭艳英[1] 赵蕾[1] 王坤[1] 沙根德克.耶里节夫 何秉贤[1] 

机构地区：[1]新疆医科大学第一附属医院心内科,乌鲁木齐830054

出　　处：《国际遗传学杂志》2006年第6期476-477,480,共3页International Journal of Genetics

摘　　要：目的检测新疆哈萨克族人群中β3肾上腺素能受体(β3-adrenergic receptor,β3-AR) Trp64Arg位点的等位基因频率和基因型频率,分析β3-AR基因在高血压病发生、发展中的作用。方法应用聚合酶链反应和限制性片段长度多态性技术检测189例高血压病、197例血压正常高值和135例正常人的基因型,同时测定相关的生化指标,并进行病例-对照统计学分析。结果β3-AR Trp64Arg位点的基因型频率在3组间无统计学差异。结论β3-AR Trp64Arg多态性与哈萨克族高血压病的发生无明显关联。Objective To investigate the genotype of Trp64Arg polymorphism ofβ3-adrenergic receptor gene and analyze the role of the gene in the pathogenesis of essential hypertension. Methods PCR-restriction fragment length polymorphism was used to detect the genotypes of 189 hypertensives and 197 bordertensives and 135 normotensives, and some biochemical indexes were tested. The association of the polymorphism with essential hypertension was assessed in a case-control study. Results No statistically significant diffe...

关 键 词：高血压病 Β3肾上腺素能受体基因 遗传多态性 哈萨克民族 

分 类 号：R544.1[医药卫生—心血管疾病]