抗脑血栓片对大鼠缺血性脑损伤保护作用的实验研究  

Effect of Kang Naoxueshuan Tablet on Protecting Ischemic Brain Injury in Rats

作　　者：桂玲[1] 郭莲军[1] 徐旭林[1] 曲玲[1] 罗璨[1] 

机构地区：[1]华中科技大学同济医学院药理系,武汉430030

出　　处：《中国中西医结合杂志》2006年第S1期7-10,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察抗脑血栓片对缺血性脑损伤的保护作用,并初步探讨其可能的作用机制。方法大鼠灌胃给予抗脑血栓片,连续14天,每天2次。采用大鼠大脑中动脉栓塞(MCAO),制作急性局灶性脑梗塞动物模型,观察缺血24h后对脑梗塞体积和神经行为学变化的影响,以及对大鼠体外血栓形成、血小板聚集、血液黏度等指标的影响。结果抗脑血栓片可依剂量性减轻大鼠局灶性脑缺血所致的脑梗塞体积以及改善由脑缺血引起的神经症状。大、中、小剂量组脑梗塞体积分别为(11．18±3．35)%、(14．60±7．00)%和(15．37±7．21)%,与模型组(27．51±4．71)%比较,各组依次分别下降59．36%、46．93%和44．13%(P＜0．01),各剂量组对体外血栓的干、湿重量均亦可明显减轻,与模型组比较,差异有显著性(P＜0．05,P＜0．01),可显著抑制ADP诱导的血小板聚集,降低全血黏度,但对血浆黏度、红细胞压积无明显影响。结论抗脑血栓片对脑缺血有明显的保护作用,其作用可能与它改善血液黏度、抑制血小板聚集有关,对其确切作用机制,有待深入研究。Objective To observe the protective effect of Kang Naoxueshuan Tablet (KNT) on ischemic brain injury in rats,and explore its possible mechanism.Methods Rats were administrated with KNT twice per day for successive 14 days.Rat model of acute focal cerebral ischemia was established by middle cerebral artery occlusion (MCAO) with a nylon suture inserted through the right internal carotid artery to occlude the beginning of middle cerebral artery.After 24 hrs MCAO,the neurological deficit and the volume of cereb...

关 键 词：抗脑血栓片 大脑中动脉阻塞 脑梗塞体积 血小板聚集 血液黏度 

分 类 号：R285[医药卫生—中药学]