T细胞蛋白酪氨酸磷酸酶在信号转导中的作用  

The Role of T-cell Protein Tyrosine Phosphatase in Signal Transduction

作　　者：曹校校[1] 唐圣松[1] 

机构地区：[1]南华大学肿瘤研究所,湖南衡阳421001

出　　处：《南华大学学报（医学版）》2006年第5期644-647,共4页Journal of Nanhua University(Medical Edition)

摘　　要：近年来,T细胞蛋白酪氨酸磷酸酶TCPTP已经成为PTP家族的重要成员。主要功能有两方面:一是TCPTP能够去磷酸化细胞中许多酪氨酸磷酸化的蛋白,如EGFR、STAT、JAK等,表明其在细胞信号通路中有负性调节作用。二是TCPTP-/-的小鼠表现为造血功能低下和免疫系统功能紊乱,表明其在造血组织和免疫调节中也起着重要作用。本篇综述主要对TCPTP在信号转导方面的作用做一总结。In recent years,the T-cell protein tyrosine phosphatase(TCPTP) has become an important member of the proteintyrosine phosphatase(PTP) family in two aspects.Firstly,TC-PTP has been reported to act on downstream signaling events initiated by EGFR、STAT and so on,suggestingthat it may act as an important modulator of receptor tyrosine kinases and mitogenic signalling.Secondly,the finding of immune deficiency and lethality observed in TCPTP null mice emphasizes the importance of this small PTP in the hematopoiet...

关 键 词：T细胞蛋白酪氨酸磷酸酶 信号转导 免疫炎症 

分 类 号：R392.1[医药卫生—免疫学]