四药联用治疗糖尿病难治性溃疡22例效果观察  

Observation of the efficacy of the drug combination of 4 kinds of drugs in the treatment of 22 cases of refractory diabetic ulcer

作　　者：陈锋[1] 郑河清[1] 施孔江[1] 黄小梅[1] 

机构地区：[1]广东医学院第二附属医院,广东湛江524003

出　　处：《齐鲁护理杂志》2006年第21期2083-2084,共2页Journal of Qilu Nursing

摘　　要：目的:探讨山莨菪碱、胰岛素、10%皮维碘软膏和利福平四药联用局部治疗糖尿病难治性溃疡的疗效。方法:将41例糖尿病难治性溃疡患者随机分为两组,对照组19例给予常规换药治疗,观察组22例在局部清创基础上给予山莨菪碱、胰岛素喷洒创面,然后将上述药液与10%皮维碘软膏、利福平混合均匀涂在创面上。结果:观察组平均愈合时间65.2±4.5d,溃疡愈合率为95.5%;对照组平均愈合时间70.3±4.5d,溃疡愈合率为47.4%。两组比较均有显著性差异(P<0.01)。结论:四药联用可显著提高糖尿病难治性溃疡愈合率,值得推广应用。Objective: To explore the efficacy of the local treatment of combination of anisodamine,insulin,10% Piweidian ointment and rifampin for refractory diabetic ulcer.Methods: Forty one patients with refractory diabetic ulcer were randomly divided into control group(n=19) and observation group(n=22).The conventional treatment was taken in control group,and in observation group the patients were sprayed anisodamine and insulin,and then 10% Piweidian ointment and rifampin were smeared in the surface of wound locally after clearing the wound.Results: The mean time of healing was 65.2±4.5d and the rate of healing was 95.5% in observation group,and in control group the mean time of healing and the rate of healing were 70.3±4.5d and 47.4%.There was significant difference in the comparison between the two groups(P<0.01).Conclusion: The drug combination of 4 kinds of drugs can evidently increase the rate of healing in the treatment of refractory diabetic ulcer.

关 键 词：糖尿病 难治性溃疡 山莨菪碱 胰岛素 利福平 

分 类 号：R473.5[医药卫生—护理学]