N-甲基羟胺与O-甲基烃胺对1-苯基-2-硝基丙烯的加成反应  

Nucleophilic addition of N-methylhydroxylamine and O-methylhydroxylamine to 2-ntryl-1-phenylpropene

作　　者：邓昌辉[1] 张力[2] 郭洪声[2] 

机构地区：[1]武警医学院继续教育处,天津300162 [2]武警医学院化学教研室,天津300162

出　　处：《武警医学院学报》2006年第4期308-310,共3页Acta Academiae Medicinae CPAPF

摘　　要：【目的】研究N-甲基羟胺与O-甲基羟胺对不饱和硝基化合物的加成反应。【方法】N-甲基羟胺和O-甲基羟胺分别与不饱和硝基化合物进行亲核加成,反应产物通过色谱分离后计算产率并经1HNMR进行结构确认;利用Gaussian计算程序,由AM1半经验方法得到加成产物的最稳定构象。【结果】1HNMR图谱证实了加成产物结构的正确性;计算得到产物的产率及最稳构象。【结论】通过本实验方法可以得到目标产物,产物的产率提示N-甲基羟胺的加成反应具有立体选择性。【Objective】To study the nucleophilic addition of N-methylhydroxylamine and O-methylhydroxylamine to unsaturated nitro compounds.【Methods】Unsaturated nitro compounds proceeding nucleophilic addition reaction with N-methylhydroxylamine and O-methylhydroxylamine respectively.After the products being separated by HPLC,the yields were calculated and the structure of products was verified by()~1HNMR.The most stable conformation of the addition product was obtained through Gaussian program calculation.【Results】The structure of products were confirmed by()~1HNMR.The most stable conformation of products were got by Gaussian program calculation,and the yield was calculated.【Conclusion】The desired products were got via the empirical method in this paper.The yield of products imply that the nucleophilic addition of Nmethylhydroxylamine to unsaturated nitro compounds give stereoselectivity.

关 键 词：加成反应 N-甲基羟胺 O-甲基羟胺 最稳定构象 

分 类 号：R313[医药卫生—基础医学]