对氯苯甲醛卤素交换氟化新工艺研究  

Study of halogen-exchange fluorination of 4-chlorobenzaldehyde

作　　者：梁政勇[1] 徐珍[1] 李斌栋[1] 吕春绪[1] 

机构地区：[1]南京理工大学化工学院,江苏南京210094

出　　处：《现代化工》2006年第z1期209-212,共4页Modern Chemical Industry

基　　金：江苏省科技攻关项目(BE2004045)

摘　　要：研究了以对氯苯甲醛(PCAD)和无水KF为原料合成对氟苯甲醛(PFAD)的氟化反应。在溶剂选择、催化机理、工艺优化、动力学以及副反应研究等方面进行了相关探讨。在以硝基苯为溶剂,n(KF)∶n(PCAD)∶n(Ph4PBr)∶n(催化剂A)=3∶1∶0.1∶0.05、反应温度210℃、反应时间8 h的最佳工艺条件下,产品对氟苯甲醛的收率可达80.9%,纯度99.5%以上。The fluorination of 4-chlorobenzaldehyde was studied in solvents using spray-dried KF as fluorinating agent.In addition,the factors influencing the yield were discussed on solvents selecting,catalytic mechanism,process optimizing,dynamical equation and by-reaction control.Under the optimum reaction conditions as n(KF)∶n(PCAD)∶n(Ph_4PBr)∶n(Cat.A)=3∶1∶0.1∶0.05,reacting at 210℃ for 8 h with nitrobenzene as a solvent,the yield of 4-fluorobenzaldehyde can reach 80.9% with purity of higher than 99.5%.

关 键 词：对氯苯甲醛 对氟苯甲醛 卤素交换氟化 相转移催化 防脱卤剂 

分 类 号：TQ244.4[化学工程—有机化工]