冠心病患者血清白细胞介素-8、可溶性细胞间黏附分子-1水平和血脂异常的关系  

Levels of serum interleukin-8 and soluble cell adhesion molecule-1 in patients with coronary heart disease and their relationship with dyslipidemia

作　　者：张雄[1] 饶玲璋[1] 

机构地区：[1]湖北省武汉市武昌铁路医院,430063

出　　处：《检验医学与临床》2006年第8期363-364,共2页Laboratory Medicine and Clinic

摘　　要：目的检测冠心病(CHD)患者血清白细胞介素-8(IL-8)、可溶性细胞间黏附分子-1(sICAM-1)和血脂的水平,探讨其在CHD发病机制中的意义。方法采用全自动生化分析仪和双抗夹心酶联免疫吸附试验(ELISA)技术检测86例冠心病患者血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)和IL-8、sICAM-1水平,并以30例正常对照组进行比较。结果CHD患者血清TC、TG、IL-8和sICAM-1水平明显高于正常对照组,其差异有统计学意义(P<0.01),而HDL-C水平显著低于正常对照组,差异有统计学意义(P<0.01);CHD患者血脂异常组(CHD2)IL-8、sICAM-1水平高于血脂正常组(CHD1),其差异有统计学意义(P<0.01)。结论IL-8和sICAM-1与血脂异常之间存在一定联系,3者可能参与了CHD的发病过程。Objective To investigate the significance in the pathogenicity of coronary heart disease (CHD) by measuring the levels of serum interleukin-8(IL-8) and solube cell adhesion molecule-1 (sICAM-1) in the patients with CHD.Methods The levels of TC, TG, HDL-C, IL-8 and sICAM-1 in 86 patients with CHD were detected by total-automatic biochemical analyzer and the method of enzyme-linked immunosobant assay (ELISA), comparing with 30 cases of health controls.Results The serum levels of TC, TG, IL-8 and sICAM-1 in the patients with CHD were higher than those in the health controls significantly (P<0.01), but the serum levels of HDL-C were lower than those in the health controls significantly (P<0.01);among 86 patients with CHD,the serum levels of IL-8 and sICAM-1 in the dyslipidemia group were significantly higher than those in the ortholiposis group (P<0.01).Conclusion The high level of IL-8,sICAM-1, TC and TG, and the low level of HDL-C may play important roles in leading to the pathogenesis of CHD, and there is interactive correlation among these changes.

关 键 词：冠心病 白细胞介素-8 可溶性细胞间黏附分子-1 

分 类 号：R541.4[医药卫生—心血管疾病]