苦参碱联合大剂量丹参注射液治疗病毒性肝炎高胆红素血症临床观察  

Clinical Observation on the treatment for Hyperbilirubinemia of Viral Hepatitis with Matrine combined with higher doses Danshen Injection

作　　者：赵宇亮 黎艳华 葛凤兰 

机构地区：[1]焦作市第三人民医院,河南焦作454172

出　　处：《中国实用医药》2006年第5期25-26,共2页China Practical Medicine

摘　　要：目的探讨苦参碱联合大剂量丹参注射液治疗病毒性肝炎高胆红素血症的疗效与安全性。方法病毒性肝炎高胆红素患者60例随机分为治疗组和对照组,每组各30例,对照组给予甘草酸二铵、门冬氨酸钾镁注射液、还原型谷胱甘肽、人血白蛋自、血浆等综合治疗,治疗组在综合治疗的基础上加用苦参碱注射液250ml/瓶,内含苦参碱150mg/瓶及丹参注射液40ml加入5%葡萄糖注射液250ml中缓慢静脉滴注,每日一次,4周为一疗程。结果两组患者治疗前后TBiL、ALT、PT均显著下降;两组治疗后比较,治疗组的TBiL、PT下降幅度显著大于对照组(P<0.01),而ALT的下降幅度两组比较差异无显著性(P>0.05),不良反应轻微。结论苦参碱联合大剂量丹参注射液治疗病毒性肝炎高胆红素血症有较好的疗效与安全性。Objective To evaluate the efficacy and safety of the treatment for Hyperbilirubinemia of Viral Hepatitis with Matrine combined with higher doses Danshen Injection.Methods 60 patients with hyperbilirubinemia of viral hepatitis randomly divided into treatment group and control group. In the control group every patient was given diammonium Glycyrrhizinate?Potassium Magnesium Aspartate Injection?TAD?Human Albumin?Blood Plasma etc. In the treatment group every patients was given Matrine (150mg/d) combined with Danshen Injection (40ml/d) additionally.Results During the treatment of 4 weeks, all patients showed decreased serum TBil?ALT and PT. In the treatment group, the rates of decreased serum TBil and PT significantly higher than those in the control group(P<0.01).Conclusion Matrine combined with higher doses Danshen Injection has satisfied efficacy and safety in treatment for Hyperbilirubinemia of Viral Hepatitis.

关 键 词：苦参碱 丹参注射液 病毒性肝炎 高胆红素血症 

分 类 号：R259[医药卫生—中西医结合]