吲哚胺2,3-双加氧酶与树突状细胞  

Indoleamine 2,3-dioxygenase and dendritic cells

作　　者：郭靖[1] 王震平[1] 梁华平[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所一室创伤烧伤与复合伤国家重点实验室,重庆400042

出　　处：《免疫学杂志》2006年第z1期108-110,共3页Immunological Journal

摘　　要：吲哚胺2,3-双加氧酶(IDO)是降解必需氨基酸色氨酸的限速酶,广泛表达于各种组织和细胞,在感染或炎症期间其表达量明显增高。而树突状细胞(DC)是专职的抗原提呈细胞,IDO在其内的表达可影响DC的表型和功能,进而抑制T细胞的免疫反应。研究IDO和DC的关系对深入理解IDO在免疫系统中的作用以及开发新的免疫调节策略都具有重要意义。Indoleamine 2,3-dioxygenase(IDO),a rate-limiting enzyme for the tryptophan catabolism,is widely expressed in various cells and tissues,and its production is markedly increased during infection or inflammation.Expression of IDO in dendritic cells (DC),the most powerful or 'professional' antigen presenting cells,can suppress T-cell responsiveness via influencing the phenotype and function of DCs.Studying the relationship between IDO and DCs will help us to understand more details on the role of IDO in immune system and even make it possible to develop a new immunomodulatory strategy.

关 键 词：吲哚胺2 3-双加氧酶 树突状细胞 免疫调节 

分 类 号：R392.12[医药卫生—免疫学]