亮菌多糖对S_(180)荷瘤小鼠免疫功能的研究  

Effects of Armillariella tabescens polysaccharide on immunologic function in S_(180) tumor bearing mice

作　　者：赵弋清[1] 罗霞[1] 刘高阳[1] 杨志荣[1] 

机构地区：[1]四川大学生命科学学院遗传学系,成都610064

出　　处：《免疫学杂志》2006年第z1期146-148,共3页Immunological Journal

基　　金：四川省应用基础研究项目(04JY029-047-2)

摘　　要：目的研究亮菌多糖对荷瘤小鼠免疫功能的影响。方法用S180瘤细胞建立动物模型,通过腹腔注射观察亮菌多糖对荷瘤小鼠淋巴细胞增殖反应、NK细胞活性及IL-2诱生的影响。结果亮菌多糖能够显著提高荷瘤小鼠淋巴细胞的增殖能力、NK细胞活性、显著促进脾细胞产生IL-2。结论亮菌多糖能够显著提高机体免疫调节功能。objective To investigate the immunomodulatory effect of Armillariella tabescens polysaccharide in S180 tumor bearing mice.Methods The animal model of mice bearing rumors was constructed.The lymphocyte proliferation,natural killer cell activity,and IL-2 production in the mice were measured after intraperitoneal injection of Armillariella tabescens polysaccharide.Results Armillariella tabescens polysaccharide markedly improved lymphocyte proliferation,natural killer cell activity,and IL-2 production in S180 tumor bearing mice.Conclusion Armillariella tabescens polysaccharide can improve the immunological function of S180 tumor bearing mice.

关 键 词：亮菌多糖 荷瘤小鼠 免疫 

分 类 号：R392[医药卫生—免疫学]