LIG抗炎,解热活性的研究(英文)  

Anti-inflammatory and Antipyretic Activities of Z-ligustilide

作　　者：姚尧[1] 杜俊蓉[1] 白波[1] 汪成远[2] 钱忠明[2] 

机构地区：[1]四川大学华西药学院,成都610041 [2]香港理工大学应用生物与化学系

出　　处：《天然产物研究与开发》2006年第5期751-755,共5页Natural Product Research and Development

摘　　要：本文研究了当归提取物LIG的抗炎,解热活性。研究发现LIG(2.5,5,10 mg/kg)对角叉菜和右旋糖苷诱导的足肿胀的抑制率分别为22.2%,49.4%,76.5%和20.8%,44.2%,75.3%(P<0.001);对棉球肉芽肿的抑制率为29.2%,44.9%,58.8%(P<0.001);对小鼠白细胞迁移的抑制率为20.7%,35.6%,48.2%(P<0.001)。此外,LIG可降低啤酒酵母导致的高热(P<0.001)。并且,LIG的抗炎,解热作用均成剂量依赖性。以上结果显示LIG具有非常强的抗炎,解热活性。In this study,the anti-inflammatory,analgesic and antipyretic effects of Z-ligustilide(LIG) extracted from Radix angelicae sinensis were investigated.The effects of LIG(2.5,5 and 10 mg/kg,ig) on acute and chronic phases of inflammation were studied in carrageenan-and dextran-induced paw edema and cotton pellet-induced granuloma,respectively.Antipyretic activity of LIG was evaluated in yeast-induced hyperpyrexia model in rats.In the anti-inflammatory studies,LIG showed significant dose-dependent inhibition of 22.2%,49.4% and 76.5% and 20.8%,44.2% and 75.3% in carrageenan-and dextran-induced paw edema,and 29.2%,44.9% and 58.8% in cotton pellet-induced granuloma,respectively(P<0.001).LIG also exhibited significant dose-dependent inhibition of peritoneal leukocyte migration in mice at the inhibition rate of 20.7,35.6 and 48.2%(P<0.001).Oral administration of LIG significantly reduced the elevated temperature in rats(P< 0.001).The results suggest that LIG possesses potent anti-inflammatory and analgesic activities.

关 键 词：当归 抗炎 解热 足肿胀 肉芽肿 

分 类 号：R282.71/.77⑨05[医药卫生—中药学] Q946[医药卫生—中医学]