狼疮性肾炎患者尿单核细胞趋化蛋白-1与细胞免疫水平及其相关性分析  

Study on the Level of Urine MCP-1 and Cellular Immunity and the Relativity between Them

作　　者：程慧玲[1] 林梅青[1] 张丽[1] 刘建伟[2] 

机构地区：[1]山东省千佛山医院,山东济南250014 [2]山东大学齐鲁医院,山东济南250012

出　　处：《预防医学论坛》2006年第6期649-651,共3页Preventive Medicine Tribune

基　　金：山东省卫生厅资助项目(项目号:2005HK077)

摘　　要：[目的]探讨狼疮性肾炎患者尿单核细胞趋化蛋白-1(MCP-1)水平变化的临床意义及其与细胞免疫的相关关系。[方法]2002～2006年对山东省千佛山医院和山东大学齐鲁医院住院、门诊的40例活动性狼疮性肾炎(LN)病人尿中单核细胞趋化蛋白-1(MCP-1)水平与外周血CD4+、CD8+、CD3+细胞数变化及其与细胞免疫的相关关系。[结果]尿MCP-1(pg/ml)25例LN活动期病人为(1298±396),15例稳定期LN病人为(449±181),30名正常对照为(145±110)(P<0.01)。活动期LN组与对照组比较,CD4+、CD3+、CD8+细胞数升高,CD4+/CD8+明显降低(P<0.05或P<0.01);活动期LN与稳定期LN比较,CD4+、CD3+、CD8+细胞数与CD4+/CD8+比值的差异均无统计学意义(P>0.05);稳定期LN组与对照组比较,CD4+、CD3+细胞数的差异无统计学意义(P>0.05),CD8+细胞数升高(P<0.01),CD4+/CD8+比值降低(P<0.05)。活动期LN病人尿中MCP-1与CD4+、CD4+/CD8+均呈负相关(r=-0.41、-0.42),与CD8+、DAI呈正相关(r=0.43、0.63),与CD3+未见相关性。[结论]尿MCP-1水平可作为了解LN患者肾病活动性病变的一个指标,与细胞免疫有相关性。[Objective]To investigate the clinical significance of the level change of urinary monocyte chmoattractant protein-1(MCP-1)in lupus nephritis(LN)patients and the relativity between it and cellular immunity.[Methods]The level of urinary MCP-1 and the count of CD4～+,CD3～+,CD8～+ were tested for 40 reactive LN patients form Shandong provincial Qianfosham hospital and affiliated hospital of Shandong university and the relativity between them was study.[Results]The urinary MCP-1(pg/ml)level in active LN patients(1 298±396)was significantly higher than those of normal controls(145±110,P<0.01),and stable LN patients(449±181,P<0.01).Compared with controls,the CD4～+,CD8～+ and CD3～+ count of the active LN patients increased,while the ratio of CD4～+ count and CD8～+ count of the active LN patients decreased significantly(P<0.05 and P<0.01);All those results between the stable LN patients and the active LN patients had no statistical differences(P>0.05);Between the stable LN patients and the Controls,there were no statistical differences of the CD4～+ and CD3～+ count(P>0.05),while the CD8～+ count increased(P<0.01),and the ratio of CD4～+ count and CD8～+ count decreased(P<0.05)for the stable LN patients.The urinary MCP-1 level was negatively correlated with CD4～+ count and CD4～+/CD8～+(r=-0.41,P<0.05;r=-0.42,P<0.05),but positively correlated with CD8～+ and DAI(r=0.43,P<0.05;r=0.68,P<0.01).It had no correlation with CD3～+.[Conclusion]Urinary MCP-1 could be used as a molecular marker to evaluate the active pathological changes of LN patients and it had obvious relationship with cellular immunity.

关 键 词：狼疮性肾炎 单核细胞趋化蛋白-1 免疫细胞 活动指数 

分 类 号：R593.2[医药卫生—内科学]