考虑冷热刀刀头温度响应对制定肿瘤治疗计划的影响  

THE EFFECT OF CONSIDERING TEMPERATURE RESPONSE OF CRYOPROBE ON TREATMENT PLANNING FOR TUMOR

作　　者：邓中山[1] 刘静[1] 周一欣[1] 

机构地区：[1]中国科学院理化技术研究所,北京100080

出　　处：《工程热物理学报》2006年第z2期41-44,共4页Journal of Engineering Thermophysics

基　　金：国家自然科学基金(No.50576104);中国科学院院长奖获得者科研启动专项资金资助项目

摘　　要：本文对冷热联合治疗肿瘤过程中在体生物组织的温度响应进行了深入的数值研究。组织被当作非理想材料,在一定的温度范围内冷冻和融化,并且考虑了未冻结组织和未损伤组织区域的血液灌注及代谢产热的影响。对比考虑和不考虑冷热刀刀头温度响应两种情形的计算结果表明,拟定治疗计划中若不考虑刀头温度响应,则有可能会造成冷热剂量的不足,从而无法彻底杀灭肿瘤。Abstract In this article, the temperature responses of in vivo biological tissues during the combined cryosurgery and hyperthermia treatments for tumor were studied through extensive numerical simulations. The tissues were treated as nonideal materials, freezing/thawing over a temperature range, and the effects of blood perfusion and metabolic heat generation in the unfrozen and undamaged tissues were also taken into account. It was indicated through comparing the computational results for the cases of considering and without considering the temperature response of cryoprobe that, inadequate cooling/heating dosages may be resulted if without considering the temperature response of cryoprobe in treatment planning, and then contributing to incomplete tumor-killing.

关 键 词：低温手术 热疗 治疗计划 肿瘤 生物传热 

分 类 号：TK124[动力工程及工程热物理—工程热物理]