甲醛对雌性小鼠生殖功能及脏器的影响  

Effect of formaldehyde on the reproduction and visceral organ of female mouse

作　　者：薛庆於[1] 陈宝定[2] 吴一丁[3] 朱军[3] 于智勇[1] 沈维干[3] 

机构地区：[1]扬州教育学院,225000 [2]江苏省邗江中学,225000 [3]扬州大学医学院,225000

出　　处：《生物学杂志》2006年第6期27-28,共3页Journal of Biology

摘　　要：采用超排卵技术研究甲醛对小鼠卵母细胞的成熟和体外受精以及脏器等的影响。甲醛对小鼠卵母细胞生发泡破裂没有影响,但可以抑制卵母细胞第一极体的释放,影响卵母细胞的存活率和破坏卵母细胞成熟,并可降低体外受精率和超排卵的卵母细胞数量,影响小鼠的正常生殖功能。而且,高剂量的甲醛还对小鼠的肝脏以及卵巢有明显的毒副作用。The effects of formaldehyde on the coefficient of visceral organ of mouse and the meiotic maturation and the fertilization ability of mouse oocytes were studied by in vitro culture and in vitro fertilization(IVF) of mouse oocytes.The results showed that high dose of formaldehyde had obviously toxicity to the liver and ovary of mice.Formaldehyde resulted in reduction of the number of superovulation oocytes.The results also showed that it could inhibit the extruding of the first polar body,interfere with the quality and the viability of mouse oocyte,and reduce the rate of IVF,but little impact on germinal vesicle breakdown(GVBD) of mouse oocyte in vivo.The results indicated that formaldehyde could disrupt the meiotic maturation of mouse oocyte,decrease the capacity of IVF and injury or make a reduction of reproductive function of mouse.

关 键 词：甲醛 卵母细胞 生发泡破裂 第一极体 体外受精 

分 类 号：Q95-33[生物学—动物学]