药效学方法测定川芎挥发油鼻腔给药的药动学参数  

The Use of a Pharmacodynamic Method for the Assay of Pharmacokinetic Parameters of Chuanxiong Rhizome Volatile Oil Administered by Nasal Drip in Rats

作　　者：潘嘉[1] 潘晓鹃[1] 张白嘉[1] 刘亚欧[1] 邹文俊[2] 

机构地区：[1]四川省中药研究所药理室,成都610041 [2]成都中医药大学,610075

出　　处：《医药导报》2006年第10期977-980,共4页Herald of Medicine

基　　金：国家中医药管理局资助项目(基金编号:02-03ZQ04)

摘　　要：目的研究川芎挥发油鼻腔给药的表观药动学参数。方法以甩尾法(温浴法)镇痛效应为指标,鼻腔给予川芎挥发油后测定其表观药动学参数。结果药动学参数鼻腔给药为:Dm in=1.101 mg.kg-1,β=0.378;t1/26 h-1,(β)=1.830 4 h,Kα=21.536 5 h-1,t1/2(Kα)=0.032 2 h,α=9.511 6 h-1,t1/2(α)=0.072 9 h,tm ax=0.739 h。结论川芎挥发油鼻腔给药的达峰时间较快,吸收迅速,起效时间短。Objective To assay the pharmacokinetic parameters of chuanxiong rhizome volatile oil administered by nasal drip with the use of a pharmacodynamic method in rats. Methods 50 SD rats serving as the subjects of the study were randomly divided into 5 equal groups.The pain threshold of the animals was determined with the tail-flick method described by H.G Vogel.107,54,36,27 mg·kg^(-1) of chuanxiong rhizome volatile oil and an equivalent amount of 0.9% sodium chloride solution was given to each rat of the 5 corresponding groups,respectively administered by nasal drip.The analgesic effect of the drug reflected by an increase in pain threshold in each animal of the 5 groups 15 min,30 min,45 min,1 h,2 h,3 h,4 h,6 h and 11 h after the nasal medication was determined for the assay of pharmacokinetic parameters of the drug. Results The pharmacokinetic parameter determined were as follows:D_(min)=1.101 mg·kg^(-1),β=0.378 6 h^(-1),t_(1/2(β))=1.830 4 h,K_(α)=(21.536 5 h^(-1)),t_(1/2(Kα))=0.032 2 h,α=9.511 6 h^(-1),t_(1/2(α))=0.072 9 h,t_(max) =0.739 h. Conclusion It was quick for the chuanxiong rhizome volatile oil to reach its peak concentration in the body of the rat.The drug was promptly absorbed and the time for the drug to start up its effect was short.

关 键 词：川芎挥发油 鼻腔给药 药动学 

分 类 号：R969.1[医药卫生—药理学]