消更延经胶囊治疗更年期综合征的机理探讨  

Approach of the Mechanism of Xiaogengyanjing Capsule Treat Menopausal Syndrome

作　　者：杨铭[1] 付萍[1] 陈影丽[1] 王清[1] 王月珍[2] 李伟[1] 

机构地区：[1]吉林省中医中药研究院,吉林长春130021 [2]吉林省西点药业科技发展股份有限公司,吉林长春130033

出　　处：《中国实验方剂学杂志》2006年第10期44-46,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨消更延经胶囊治疗更年期综合征的作用机理。方法:摘除大鼠卵巢,口服给药30d后,取血清测定E2、LH、FSH,取脑测5-HT、NE、DA、5-HIAA含量,取子宫称重。结果:给药后可使大鼠升高的血清FSH、LH水平显著降低,对明显降低的E2水平有一定的升高作用。对脑组织升高的5-HT、5-HIAA含量及5-HT/NE比值均有明显的降低作用,但对NE、DA含量及5-HIAA/5-HT比值无明显影响。增加去卵巢大鼠体重和子宫重量。结论:消更延经胶囊可通过调节性腺和植物神经机能改善和治疗更年期综合征。Objective:To discuss the mechanism of 'Xiao Geng Yan Jing' capsule for treating menopausal syndrome.Methods:Extirpation of ovaries of rats was cartied out.After 30 days of oral administration,serum was collected to determine the contents of estradiol(E_2)、luteinizing hormone(LH)、follicle-stimulation hormone(FSH),The contents of 5-hydroxytryptamine(5-HT)、norepinephrine(NE)、dopamine(DA) and 5-hydroxyindoleacetic acid(5-HIAA) in brain was determined.The uterus was weighed.Results:The experiment showed that 'Xiao Geng Yan Jing' capsule could decrease the levels of FSH and LH obviously,and increase the level of E_2.For the brain of castrated rats,it could decrease 5-HT、5-HIAA contents and 5-HT/NE.But for NE、DA contents and 5-HIAA/5-HT it have no influence.Moreover,this medicine can increase the weight of the castrated rat and their uterus.Conclusion:'Xiao Geng Yah Jing' capsule can improve and treat menopausal syndrome though the mechanism of adjusting sexual gland and nervous function.

关 键 词：消更延经胶囊 性激素 卵巢 

分 类 号：R285.5[医药卫生—中药学]