经典恒温法和初匀速法考察注射用替卡西林钠/克拉维酸钾溶液的稳定性  

Investigation of the stability of the Ticacillin sodium and Clavulanate potassium for injection by classic isothermal kinetic method and initial uniform velocity method

作　　者：徐恒[1] 吕露阳[2] 方梅[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]成都英创科技有限公司,四川成都610041

出　　处：《华西药学杂志》2008年第2期178-180,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究注射用替卡西林钠/克拉维酸钾(TCS/CLP)的稳定性和有效期。方法用HPLC测定TCS/CLP的含量和有关物质,采用经典恒温法和初匀速法计算有效期。结果TCS/CLP在水溶液中的降解符合一级动力学方程。经典恒温法测得25℃时降解5%的时间分别为25.73、13.94 h。初匀速法测得值分别为24.89、14.00 h。结论两种方法测得数据基本一致,初匀速法可用于预测有效期。TCS/CLP在水溶液中不稳定,应随配随用。OBJECTIVE To investigate the stability and expiration date of Ticacillin sodium(TCS) and Clavulanate potassium(CLP) injection solution.METHODSThe HPLC method was used to determine the contents and related substances of the solution.Classic isothermal kinetic method and initial uniform velocity method were applied to predict the expiration date of the solution.RESULTSIt was found that the TCS and CLP injection solution corresponded with the first-order kinetics.TCS declined by 5% in 25.73 h and CLP declined ...

关 键 词：注射用替卡西林钠/克拉维酸钾 高效液相色谱法 经典恒温法 初匀速度法 溶液稳定性 

分 类 号：R927[医药卫生—药学]