复方银黄微型灌肠剂对发热大鼠环氧化酶蛋白表达的调节  

Effect of Compound Yinhuang micro-enema on proteins expression of cyclooxygenase in fever rats

作　　者：阳洁[1] 刘华钢[1] 赖茂祥[2] 朱丹 杨斌[1] 

机构地区：[1]广西医科大学药学院,广西南宁530021 [2]广西中医药研究所,广西南宁530022

出　　处：《华西药学杂志》2008年第3期301-303,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:30260124)

摘　　要：目的探讨复方银黄微型灌肠剂(YHCE)对发热大鼠环氧化酶(COX)蛋白表达的调节作用。方法用酵母混悬液制备发热大鼠模型,用免疫组化法检测大鼠下丘脑中COX-1、COX-2蛋白表达的变化。结果YHCE能明显抑制发热大鼠的体温上升,抑制下丘脑中COX-2的蛋白表达,而对下丘脑中COX-1的蛋白表达无明显影响。结论YHCE的解热作用机制之一可能与其调节COX-2的蛋白表达有关。OBJECTIVE To study the effect of Compound Yinhuang micro-enema(YHCE) on proteins expression of cyclooxygenase(COX) in fever rats.METHODS The animal models were induced by injecting suspension of yeast hypodermically.The proteins expression changes of COX in hypothalamus of rats were detected by immunohistochemistry.RESULTS YHCE could significantly inhibite the temperature rise and the protein expression of COX-2.But it has no obvious effect on the protein expression of COX-1.CONCLUSION One of antipyretic ef...

关 键 词：复方银黄微型灌肠剂 解热 环氧化酶 免疫组化 

分 类 号：R285[医药卫生—中药学]