灵芝多糖预防大鼠动脉粥样硬化的实验研究  

Preventive effect of Ganoderma lucidum polysaccharides on formation of atherosclerosis in experimental rats

作　　者：吴锋[1] 孟国梁[1] 杨丽云[1] 赵喜[1] 徐济良[1] 

机构地区：[1]南通大学医学院药理学教研室,南通226001

出　　处：《南通大学学报（医学版）》2008年第4期251-252,255,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市科技创新计划项目(A5013)

摘　　要：目的:探讨灵芝多糖对食饵性实验动脉粥样硬化大鼠动脉粥样硬化形成的作用及机制。方法:将24只大鼠随机分为正常对照组、动脉粥样硬化模型组、灵芝多糖预防组。12周末颈动脉取血检测血清甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)和脂蛋白a[Lp(a)]含量。处死大鼠,光镜观察主动脉粥样斑块形成情况。结果:与动脉粥样硬化模型组比较,灵芝多糖预防组大鼠血清TG、TC、LDL、Lp(a)含量明显降低(P<0.05),主动脉内膜泡沫细胞数量明显减少。结论:灵芝多糖具有防止大鼠动脉粥样硬化形成的作用,其机制可能和调节血脂障碍有关。Objective:To study the preventive effect and the mechanism of Ganoderma lucidum polysaccharides (GLP) on formation of atherosclerosis in experimental atherosclerotic rats.Methods:24 rats were divided randomly into normal control group,atherosclerotic model group,treatment group with GLP.At the end of the 12th week after experiment,The levels of serum total cholesterol (TC),triglyeerides (TG),low density lipoprotein cholesterol (LDL),high density lipoprotein (HDL) and lipoprotein(a) [Lp(a)] were determined r...

关 键 词：动脉粥样硬化 灵芝多糖 大鼠 

分 类 号：R285.5[医药卫生—中药学]