罗格列酮对2型糖尿病合并高尿酸血症患者尿酸和颈动脉硬化的影响  

The effect of rosiglitazone on the level of serum uric acid and carotid atherosclerosis in patients with type 2 diabetes mellitus and hyperuricemia

作　　者：郁卫刚[1] 郭晓珍[1] 俞海燕[1] 孙军卫[1] 施广德[1] 黄文龙[1] 方铭[1] 吴心池[1] 

机构地区：[1]南通大学附属江阴医院内分泌科,江阴214400

出　　处：《南通大学学报（医学版）》2008年第4期276-278,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:观察罗格列酮对2型糖尿病合并高尿酸血症患者尿酸和颈动脉硬化的影响。方法:将2型糖尿病110例合并高尿酸血症患者随机分成两组。对照组维持原治疗;观察组在原治疗基础上给予罗格列酮4 mg/d治疗。治疗前及干预3个月和6个月分别检测血糖、血脂、血尿酸和肾功能,用超声多普勒检查双侧颈动脉内中膜厚度、管腔内径、动脉粥样硬化斑块的数量和类型。结果:给予罗格列酮干预3个月血尿酸水平无明显下降(P>0.05),干预6个月血尿酸水平明显下降(P<0.05)。罗格列酮干预6个月颈动脉内中膜厚度减少、管腔内径增大、动脉粥样硬化斑块的数量减少和类型改变与治疗前相比差异有统计学意义(P<0.05)。结论:罗格列酮能降低合并高尿酸血症的2型糖尿病患者的血尿酸,延缓其颈动脉硬化斑块的发生和稳定斑块,有利于防治糖尿病大血管并发症的发生和发展。Objective:To observe the effect of rosiglitazone on the level of serum uric acid and carotid atherosclerosis in patients with type 2 diabetes mellitus and hyperuricemia.Methods:One hundred and ten cases of type 2 diabetes mellitus with hyperuricemia were randomly divided into treatment group and control group.The control group received routine therapy alone.The treatment group were treated with rosiglitazone 4 mg/d on the basis routine therapy for six months.The level of serum uric acid,blood glucose,lipid ...

关 键 词：2型糖尿病 高尿酸血症 罗格列酮 颈动脉硬化 

分 类 号：R587.1[医药卫生—内分泌]