丹参酮Ⅱ_A与丹参酮Ⅱ_A磺酸钠在小鼠体内的分布  

Biodistribution of tanshinone Ⅱ_A and sodium tanshinone Ⅱ_A sulfonate in mice after intravenous administration

作　　者：梁臻[1] 毛声俊[1] 尹宗宁[1] 金辉[1] 吴宇[1] 储婷[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2008年第4期416-419,共4页West China Journal of Pharmaceutical Sciences

基　　金：高等学校博士点基金新教师项目(编号:20070610050)

摘　　要：目的考察静脉注射丹参酮ⅡA与丹参酮ⅡA磺酸钠后,二者在小鼠体内的分布行为,证实两者穿透血脑屏障的差异。方法小鼠分别静脉给予丹参酮ⅡA乳剂与丹参酮ⅡA磺酸钠注射液,以HPLC法测定各主要脏器组织中的药物含量。结果丹参酮ⅡA乳剂与丹参酮ⅡA磺酸钠静脉给药后均快速分布至各主要脏器组织,其中以肝脏的药物分布量最高;前者在脑组织中的分布明显高于后者。结论丹参酮Ⅱ比丹参酮ⅡA磺酸钠更易进入血脑屏障,提示丹参酮ⅡA乳剂有望用于脑血管病的预防和治疗。OBJECTIVE To compare the biodistribution of tanshinone ⅡA and sodium tanshinone ⅡA sulfonate in mice after intravenous administration.METHODS The self-made tanshinone ⅡA emulsion and the saled injection of sodium tanshinone ⅡA sulfonate were intravenously administrated,respectively.Tanshinone ⅡA and sodium tanshinone ⅡA sulfonate were separately determined by HPLC.RESULTS Both tanshinone ⅡA and sodium tanshinone ⅡA sulfonate have rapid distribution to the main organs and tissues,especially to the liver.The ...

关 键 词：丹参酮ⅡA 丹参酮ⅡA磺酸钠 乳剂 体内分布 

分 类 号：R285[医药卫生—中药学]