羟喜树碱磷脂复合物理化性质的研究  

Study on the physico-chemical properties of hydroxycamptothecin-phospholipid complex

作　　者：卫薇[1] 赵栋[1] 张志荣[1] 龚涛[1] 

机构地区：[1]四川大学靶向药物教育部重点实验室,四川成都610041

出　　处：《华西药学杂志》2008年第4期396-399,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究羟喜树碱磷脂复合物的理化性质。方法用溶剂法制备羟喜树碱磷脂复合物,测定其在水中的溶解度和分散性,以差示扫描量热法研究其热力学性质,以X-射线衍射法研究羟喜树碱在磷脂中的存在状态。结果复合物中羟喜树碱在水中的溶解度显著增大,水中很容易分散形成纳米粒。DSC图谱表明复合物是不同于羟喜树碱、磷脂以及二者物理混合物的新物相。X-射线衍射表明在复合物中羟喜树碱与磷脂作用以无定形形态存在。结论羟喜树碱与磷脂形成复合物后,其理化性质发生明显变化。OBJECTIVE To study the physico-chemical properties of hydroxycamptothecin-phospholipid complex.METHODS The complex was prepared by solvent evaporation method and the water solubility of hydroxycamptothecin in complex was determined.The dispersity of complex in water was also determined.The thermodynamic properties of complex were studied by DSC and the physical state of hydroxycamptothecin in phospholipid was investigated by X-ray diffraction.RESULTS Compared with hydroxycamptothecin and physical mixture,th...

关 键 词：羟喜树碱 磷脂 复合物 

分 类 号：R913[医药卫生—药学]