砂生槐种子水提物的S_(180)小鼠体内抗肿瘤及免疫调节作用  

Anti-tumor and immunological effects of water extracts from Sophora Moorcroftiana seed on S_(180) sarcoma in mice

作　　者：贺学强[1] 郭君[2] 

机构地区：[1]中国人民解放军第181中心医院,广西桂林541002 [2]桂林医学院基础医学院,广西桂林541002

出　　处：《华西药学杂志》2008年第4期424-426,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究砂生槐种子水提取物(SMSWE)的小鼠体内抗瘤作用,探讨其抗癌及免疫调节的意义。方法以S180荷瘤小鼠为研究对象,分别观察SMSWE各剂量组对S180荷瘤小鼠的抑瘤率、生存期、胸脾指数、T淋巴细胞增殖活性以及白细胞介素-2(IL-2)和肿瘤坏死因子-α(TNF-α)等血清细胞因子的影响和变化。结果SMSWE 1.2~2.4 g.kg-1均可抑制肿瘤的生长和延长小鼠带瘤生存时间(P<0.05),高剂量组的抑瘤率高达41.4%。SMSWE 0.6~2.4 g.kg-1可促进Con A诱导的T淋巴细胞增殖反应,中、高剂量药物组与荷瘤对照组比较具有统计学意义(P<0.05),其血清中IL-2、TNF-α的含量明显高于荷瘤对照组(P<0.05)。结论SMSWE能明显抑制S180小鼠体内肿瘤生长,具有提高荷瘤小鼠细胞免疫功能的作用。OBJECTIVE To study the anti-tumor effect of water extract substance from water extracts from Sophora Moorcroftiana seed(SMSWE) in vivo on mice.METHODS S180-bearing mice were used to assay the inhibitory rate of tumor,survival period,indexes of thymus,and spleen,the proliferative ability of T lymphocytes and the level of IL-2、TNF-α.RESULTS 1.2 to 2.4 g·kg-1of extracts could inhibit the growth of S180 tumor in mice,prolong the survival period(P<0.05),promote the proliferative ability of T hymphocytes(P<...

关 键 词：砂生槐种子水提取物 体内抗肿瘤 免疫活性调节 

分 类 号：R285.5[医药卫生—中药学]