慢性心力衰竭患者血红蛋白(Hb)、血清肿瘤坏死因子和AngⅡ水平变化及其干预研究  

The Change of Hemoglobin(Hb) Concentration, Tumor Necrosis Factor-α,Angiotensin Ⅱand Its Intervention Study in Patients with Congestive Heart Failure

作　　者：黄郁玲[1] 郗爱旗[1] 褚以德[1] 赵文蕊[1] 尚玲[1] 钟欣[1] 李英兰[1] 廖宝霞[1] 李国峰[1] 

机构地区：[1]青海省人民医院老年医学研究所,810007

出　　处：《青海医药杂志》2008年第2期1-5,共5页Qinghai Medical Journal

基　　金：青海省科技厅自然科学基金项目课题(项目编号2006-N-149)

摘　　要：目的:研究慢性心力衰竭(CHF)患者血红蛋白(Hb)、血清肿瘤坏死因子(TNF-α)和(AngⅡ)水平的变化及其干预治疗。方法:对入选的319例CHF患者分为A组和B组,并按Hb水平分为贫血组和非贫血组,于治疗前后测定了Hb、血清TNF-α和AngⅡ水平,超声心动图测量左室射血分数(LVEF),评价心功能。结果:随着心功能恶化,Hb水平逐渐降低,而血清TNF-α和AngⅡ水平逐渐升高;CHF贫血组患者血清TNF-α和AngⅡ水平明显高于非贫血组患者(P<0.01);CHF患者Hb水平与TNF-α和AngⅡ水平呈负相关(P<0.01)。采用不同方案治疗后的结果显示,联合用药治疗CHF患者优于单一药物;CHF贫血患者在贫血纠正后,血清TNF-α和AngⅡ水平恢复到非贫血组患者水平。结论:TNF-α和AngⅡ在CHF贫血发生发展的病理生理过程中起着重要作用;积极纠正贫血,规范的治疗可显著降低血清TNF-α和AngⅡ水平,从而改善CHF患者心脏功能和预后。Objective:To study the changes of hemoglobin (Hb) concentration, tumor necrosis factor-α (TNF-α), AngiotensinⅡ (AngⅡ), and the effect of intervention on Hb concentration and parameters in patients with congestive heart failure (CHF). Methods: 319 patients with CHF were divided into two group: the A group and B group. Blood samples were drawn from mediam cubital veins of the patient at the beginning of the study and follow-up after the 6-month.Hb concentration, serum level of TNF-α and AngⅡ were measured. Le...

关 键 词：心力衰竭 血红蛋白 肿瘤坏死因子-Α 血管紧张素Ⅱ 干预 

分 类 号：R541.6[医药卫生—心血管疾病]