辛伐他汀增强高脂血症大鼠的抗氧化作用实验研究  

The Effects of Simvastatin on Anti-Oxidation and Hypercholesterolemia in Rat

作　　者：杨晓玲[1] 张大军[2] 李桂忠[1] 徐华[1] 杨晓明[1] 贾月霞[1] 曹军[1] 

机构地区：[1]宁夏医学院病理生理学教研室,银川750004 [2]宁夏医学院附属医院核医学科,银川750004

出　　处：《宁夏医学院学报》2005年第6期441-442,共3页Journal of Ningxia Medical College

摘　　要：目的观察调脂药辛伐他汀对高脂血症大鼠的抗氧化作用及与血脂的关系。方法将SD大鼠随机分为正常对照组、高脂血症模型组和辛伐他汀组。对照组给予普通饮食,其余两组饲喂高脂饮食,辛伐他汀组同时给予辛伐他汀灌胃(5mg/kg.d),6周后检测各组血脂水平及抗氧化指标变化。结果与高脂血症模型组相比,辛伐他汀组大鼠血浆HDL、SOD和总抗氧化能力分别增加50%、61.12%和420.81%(P均<0.01);TC、MDA分别降低11%、10.51%(P均<0.05)。结论辛伐他汀不仅能降低血浆胆固醇的含量,还能显著增强高脂血症大鼠抗氧化能力。Objectives To explore the effects of Simvastatin on anti-oxidation and hypercholesterolemia in rat.Metheds The rats were randomly divided into 3 groups: control group,hypercholesterolemia group and Simvastatin(5mg/kg)group.Control group was administrated with full diet,other two groups were given high cholesterol food,Simvastatin group was administrated intragastrically Simvastatin 5mg/kg simultaneously.The levels of cholesterol and anti-oxidation in plasma were detected after six weeks.Results The plasma HDL,SOD level and total anti-oxidation ability significantly increased 50%,61.12 % and 420.81%(P<0.01),while,the TC and MDA level decreased 11% and 10.51%(P<0.05) in Simvastatin group than those in hypercholesterolemia group in rat.Conclusions Simvastatin not only decreases cholesterol concentration,but also increases the effects of antioxidation in plasma in hypercholesterolemia rat.

关 键 词：辛伐他汀 抗氧化 大鼠 

分 类 号：R96[医药卫生—药理学]