稳心颗粒治疗冠心病心绞痛的临床观察  

Clinical observation on wengxin grain in treating coronary heart disease with angina pectoris

作　　者：周薇霞 俞亚光[1] 汪侠敏 陈百川[1] 彭成忠[2] 俞坚武[2] 

机构地区：[1]杭州市江干区人民医院,浙江杭州310016 [2]浙江省人民医院,浙江杭州310010

出　　处：《中国现代应用药学》2005年第z1期652-654,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的比较稳心颗粒与复方丹参片治疗冠状动脉粥样硬化性心脏病(冠心病)的临床疗效。方法冠心病心绞痛患者146例,其中73例(治疗组)采用稳心颗粒口服治疗,并与复方丹参片治疗的73例(对照组)作疗效比较,2组疗程均为12周。结果经12周治疗,两药均显著降低心绞痛的发作频率、硝酸甘油日耗量并显著改善心电图NST、∑ST和运动耐量,改善心肌血的范围及程度,显著降低心率及缩压乘积,降低心肌耗氧量及提高SOD活性,降低血粘度,改善心功能。但治疗组显著优于对照组(P<0.01)。此外,两药均起效迅速,分别有79.5%与71.2%在5min内生效,持续时间4.6±4.1h,5.6±2.9h(P>0.01),基本相仿。总的症状疗效分别为:87.6%和78.08%(P>0.05),心电图总有效率90.4%和80.8%(P<0.01)。结论稳心颗粒治疗冠心病疗效显著优于复方丹参片。OBJECTIVE To compare the therapeutic efficacy of wenxin grain and composite miltiorrhiza tabler on angina pectoris with coronary heart disease(CHD).METHODS 146 cases of angina pectoris were divided into treatment group(73 cases),which was treated with oral wenxin grain and compared to control group(73 cases).which treated with composite salvia mitiorrhiza tablet;12weeks as a therapy course in both 2 groups.RESULTS For 12 weeks,Both the wenxin grain and Composite salvia miltiorrhiza tablet could not only reduce significantly the frequency of angina episode and the daily consumption of nitroglycerin,they also could result in remarkable improvement of NST、ΣST and exercise tolerance,reduce of nitroglycern does,improvnent of myocardial ischemia degree,as well as significant reduction of rate-pressure prodult.reduction of oxygen consumption and raise of superoxide dismutase activity improvement heart function.But it were superior in treatment group to those in control group(p < 0.01).In addition,the onset of action of both agents was rapid.79.5%of the study group and 71.2%of the control group were within five minutes.The sustained time of action of the two group was also similar,i.e.4.6 4.1h,5.6 2.9h(P >0.01).The tolal symptomatic effective rate of the two groups was 87.67%and 78.08%resprctively(P >0.05) and the electrocardiogram improvement rate were 90.4%and 80.8%respectively(p <0.01).CONCLUSION There are obvious therapeutic efficacy of wenxin grain on angina prctoris with CHD,it is better than composite salvia miltiorrhiza tablet.

关 键 词：稳心颗粒 复方丹参片 冠状动脉粥样硬化性心脏病 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]